LDN-192960

LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].

Product Specifications

CAS Number

[184582-62-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

DYRK; Haspin Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LDN-192960.html

Purity

99.58

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

NCCCSC1=C(C=C(OC)C=C2)C2=NC3=CC=C(OC)C=C31

Molecular Formula

C18H20N2O2S

Molecular Weight

328.43

Precautions

H315, H319, H335

References & Citations

[1]Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20 (12) :3491-4.|[2]Katrin Kestav, et al. Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin. Curr Med Chem. 2017;24 (21) :2276-2293.