LDN-192960
Product Specifications
UNSPSC Description
LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].
Target Antigen
DYRK; Haspin Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LDN-192960.html
Smiles
NCCCSC1=C(C=C(OC)C=C2)C2=NC3=CC=C(OC)C=C31
Molecular Weight
328.43
References & Citations
[1]Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3491-4.|[2]Katrin Kestav, et al. Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin. Curr Med Chem. 2017;24(21):2276-2293.Universidad de Córdoba. 2023 Sep 11.|Bioorg Chem. 2024 Apr 29:147:107412.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13455/LDN-192960-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13455/LDN-192960-SDS-MedChemExpress.pdf
CAS Number
184582-62-5
Available Sizes
Curated Selection
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