LDN-192960
LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].
Product Specifications
CAS Number
[184582-62-5]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
DYRK; Haspin Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LDN-192960.html
Purity
99.58
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
NCCCSC1=C(C=C(OC)C=C2)C2=NC3=CC=C(OC)C=C31
Molecular Formula
C18H20N2O2S
Molecular Weight
328.43
Precautions
H315, H319, H335
References & Citations
[1]Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20 (12) :3491-4.|[2]Katrin Kestav, et al. Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin. Curr Med Chem. 2017;24 (21) :2276-2293.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1; DYRK2
Citation 01
Universidad de Córdoba. 2023 Sep 11.|Bioorg Chem. 2024 Jun:147:107412.
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