4-Aminobenzohydrazide
4-Aminobenzohydrazide (p-Aminobenzohydrazide) is an irreversible myeloperoxidase (MPO) inhibitor (IC50=0.3 μM) that induces oxidative stress burst in neutrophils (ROS IC50=43.6 μM) . 4-Aminobenzohydrazide has been used in subacute stroke research[1][2][3].
Product Specifications
CAS Number
5351-17-7
Product Name Alternative
P-Aminobenzohydrazide; p-Aminobenzoic acid hydrazide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-aminobenzohydrazide.html
Purity
99.96
Solubility
DMSO : ≥ 25 mg/mL
Smiles
O=C(NN)C1=CC=C(N)C=C1
Molecular Formula
C7H9N3O
Molecular Weight
151.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Kettle AJ, et al. Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochem J. 1995 Jun 1;308 (Pt 2) (Pt 2) :559-63.|[2]Forghani R, et al. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke. J Cereb Blood Flow Metab. 2015 Mar;35 (3) :485-93.|[3]Ribeiro D, et al. Modulation of human neutrophils' oxidative burst by flavonoids. Eur J Med Chem. 2013 Sep;67:280-92.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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