4-Aminobenzohydrazide

4-Aminobenzohydrazide (p-Aminobenzohydrazide) is an irreversible myeloperoxidase (MPO) inhibitor (IC50=0.3 μM) that induces oxidative stress burst in neutrophils (ROS IC50=43.6 μM) . 4-Aminobenzohydrazide has been used in subacute stroke research[1][2][3].

Product Specifications

CAS Number

[5351-17-7]

Product Name Alternative

P-Aminobenzohydrazide; p-Aminobenzoic acid hydrazide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-aminobenzohydrazide.html

Purity

99.96

Solubility

DMSO : ≥ 25 mg/mL

Smiles

O=C(NN)C1=CC=C(N)C=C1

Molecular Formula

C7H9N3O

Molecular Weight

151.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Kettle AJ, et al. Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochem J. 1995 Jun 1;308 (Pt 2) (Pt 2) :559-63.|[2]Forghani R, et al. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke. J Cereb Blood Flow Metab. 2015 Mar;35 (3) :485-93.|[3]Ribeiro D, et al. Modulation of human neutrophils' oxidative burst by flavonoids. Eur J Med Chem. 2013 Sep;67:280-92.