5-HEPE
5-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO) . 5 (S) -HEPE is an agonist of G protein-coupled receptor 119 (GPR119) . 5 (S) -HEPE increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5 (S) -HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5 (S) -HEPE are elevated in patients with hyperlipidemia.
Product Specifications
CAS Number
[92008-51-0]
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-hepe.html
Smiles
CC/C=C\C/C=C\C/C=C\C/C=C\C=C\[C@@H](O)CCCC(O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Noguchi, et al. Action of ebselen as an antioxidant against lipid peroxidation. Biochem. Pharmacol. 44 (1), 39-44 (1992) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
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