ALDH1A inhibitor 673A

ALDH1A inhibitor 673A is an ALDH1A inhibitor with IC50s of 246 nM (ALDH1A1), 230 nM (ALDH1A2), 348 nM (ALDH1A3), respectively. ALDH1A inhibitor 673A has little or no inhibitory effect on other ALDH family members. ALDH1A inhibitor 673A induces necroptotic ovarian cancer stem-like cells (CSCs) death. ALDH1A inhibitor 673A induces DNA double stand breaks in cancer cells. ALDH1A inhibitor 673A can be used for the study of ovarian cancer[1][2][3].

Product Specifications

CAS Number

[109437-62-9]

Product Name Alternative

ALDH1Ai 673A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aldehyde Dehydrogenase (ALDH) ; Mitochondrial Metabolism; Necroptosis

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aldh1a-inhibitor-673a.html

Purity

99.15

Solubility

DMSO : 29.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1

Molecular Formula

C15H13NO

Molecular Weight

223.27

Precautions

H302, H315, H319, H335

References & Citations

[1]McGonigal S, et al. A putative role for ALDH inhibitors and chemoprevention of BRCA-mutation-driven tumors. Gynecol Oncol. 2023 Sep;176:139-146.|[2]Grimley E, et al. Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors. Theranostics. 2021 Jan 20;11 (8) :3540-3551. |[3]Chefetz I, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 Mar 12;26 (11) :3061-3075.e6.