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Timiperone

Timiperone has a strong affinity for cerebral dopamine D2 receptor. Timiperone has antipsychotic activity, and inhibits stereotyped behaviour. Timiperone can be used for research of schizophrenia[1][2][3].

Product Specifications

CAS Number

57648-21-2

UNSPSC

12352005

Hazard Statement

H301

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/timiperone.html

Solubility

10 mM in DMSO

Smiles

S=C1NC2=CC=CC=C2N1C3CCN(CC3)CCCC(C4=CC=C(C=C4)F)=O

Molecular Formula

C22H24FN3OS

Molecular Weight

397.51

Precautions

H301

References & Citations

[1]Sudo K, et al. Disposition of timiperone, 4'-fluoro-4-[4- (2-thioxo-1-benzimidazolinyl) piperidino]butyrophenone, a neuroleptic, in the rat on repeated oral dosage. Xenobiotica. 1981 Oct;11 (10) :685-91.|[2]Kariya T, et al. A comparison of the clinical effects of timiperone, a new butyrophenone derivative, and haloperidol on schizophrenia using a double-blind technique. J Int Med Res. 1983;11 (2) :66-77.|[3]Inada, K., et al. First-Generation Antipsychotics as a Bridge to Second-Generation Antipsychotics in the Japanese Pharmaceutical Industry: Mosapramine, Timiperone, Zotepine, and Nemonapride. NeuroPsychopharmacotherapy. Springer, Cham. (2021) .

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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