SRI-37240
Product Specifications
UNSPSC Description
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418[1].
Target Antigen
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sri-37240.html
Solubility
DMSO : 11.36 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1C2=C(N(C)C(N=C(N3C4CCCCC4)C5=CC=CC=C5)=C1C3=O)C=CC=C2
Molecular Weight
385.46
References & Citations
[1]Sharma J, et al. A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nat Commun. 2021 Jul 16;12(1):4358.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150089/SRI-37240-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150089/SRI-37240-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
883956-47-6
Available Sizes
Curated Selection
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