SRI-37240

SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418[1].

Product Specifications

CAS Number

[883956-47-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

CFTR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sri-37240.html

Purity

98.29

Solubility

DMSO : 11.36 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(N(C)C(N=C(N3C4CCCCC4)C5=CC=CC=C5)=C1C3=O)C=CC=C2

Molecular Formula

C24H23N3O2

Molecular Weight

385.46

Precautions

H315, H319, H335

References & Citations

[1]Sharma J, et al. A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nat Commun. 2021 Jul 16;12 (1) :4358.