Afegostat (TFA)
Afegostat TFA is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
Product Specifications
CAS Number
1084896-50-3
UNSPSC
12352005
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/afegostat-tfa.html
Smiles
OC(C(F)(F)F)=O.OC[C@@H]1[C@H]([C@@H](CNC1)O)O
Molecular Formula
C8H14F3NO5
Molecular Weight
261.20
References & Citations
[1]Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11 (4) :840-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC880050-500 1x 500 µL
IgA Secretory Component (SC05), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740266-500 1x 500 µL
Human IgG Immunoglobulin (IG266), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400391-100 1x 100 µL
CD81 / TAPA-1 (1.3.3.22), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402580-100 1x 100 µL
CD10 (Membrane Metalloendopeptidase) (MME/2580), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC741373-100 1x 100 µL
Ep-CAM / CD326 (Extracellular Domain) (Epithelial Marker) (EGP40/1373), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details