A-1248767
Product Specifications
UNSPSC Description
A-1248767 is a MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) with anticancer activity. A-1248767, a derivative of A-1210477 (HY-12468), binds to MCL-1 with high affinity, induces the increase of intracellular MCL-1 protein, and promotes tumor cell apoptosis[1].
Target Antigen
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-1248767.html
Smiles
O=C(N(C)C)N(CC1)CCN1C2=CC=C(OCC3=NN(C)C(C)=C3C4=C(N(CCN5CCOCC5)C(C(O)=O)=C6CCCOC7=C(C=CC=C8)C8=CC=C7)C6=CC=C4)C=C2
Molecular Weight
813.98
References & Citations
[1]Leverson, et al. "Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)." Cell death & disease 6.1 (2015): e1590-e1590.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164453/A-1248767-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164453/
Clinical Information
No Development Reported
CAS Number
2228052-38-6
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