STK17A/B-IN-1

STK17A/B-IN-1 (compound 9) is an orally active, potent, and selective STK17A/B inhibitor with an IC50 of 23 nM against STK17A. STK17A/B-IN-1 can be used for study of cancer[1].

Product Specifications

CAS Number

[3002038-21-0]

UNSPSC

12352005

Target

DAPK

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stk17a-b-in-1.html

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(NC2=NC=CC(C3=CC4=C(N=C(N5CCCC5)N=C4)C=C3)=N2)C=C1)NC(C)C

Molecular Formula

C26H27N7O

Molecular Weight

453.54

References & Citations

[1]Chaudhry S, et al. Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors. ACS Med Chem Lett. 2024;15 (6) :945-949. Published 2024 May 20.