Sotorasib (racemate)
Product Specifications
Product Name Alternative
Stibogluconate (trisodium nonahydrate)
UNSPSC Description
Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib (HY-114277), a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research[1].
Target Antigen
p38 MAPK; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AMG-510_racemate.html
Purity
98.99
Solubility
DMSO : 3.85 mg/mL (ultrasonic)
Smiles
O=C1N(C2=C(C)C=CN=C2C(C)C)C3=NC(C4=C(O)C=CC=C4F)=C(F)C=C3C(N5[C@@H](C)CN(C(C=C)=O)CC5)=N1
Molecular Weight
560.59
References & Citations
[1]Karen Rex, et al. Abstract 3090: In vivo characterization of AMG 510 - a potent and selective KRASG12Ccovalent small molecule inhibitor in preclinical KRASG12Ccancer models. Experimental and Molecular Therapeutics.|[2]Beltran, P, et al. Combination therapy comprising substituted pyrimidin-4(3H)-ones and sotorasib for treating cancer in subjects with KRAS gene mutations. International, WO 2023/056037 A1.2023-04-06.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114277A/Sotorasib-racemate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114277A/Sotorasib-racemate-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
2252403-56-6
Available Sizes
Curated Selection
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