Propoxur (Standard)
Propoxue (Standard) is the analytical standard of Propoxue. This product is intended for research and analytical applications. Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests[1][2][3].
Product Specifications
CAS Number
114-26-1
UNSPSC
12352005
Target
Cholinesterase (ChE) ; ERK; Insecticide; Keap1-Nrf2; MMP; Reactive Oxygen Species (ROS) ; Reference Standards
Type
Reference Standards
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; Stem Cell/Wnt
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/propoxur-standard.html
Purity
99.28
Smiles
CC(C)OC1=CC=CC=C1OC(NC)=O
Molecular Formula
C11H15NO3
Molecular Weight
209.24
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
No Development Reported
Isoform
AChE; MMP-2
Available Sizes
Frequently Asked Questions
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