1-Azakenpaullone
1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1].
Product Specifications
CAS Number
676596-65-9
Product Name Alternative
1-Akp
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/1-azakenpaullone.html
Purity
99.61
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CN=C12)CC3=C2NC4=C3C=C(Br)C=C4
Molecular Formula
C15H10BrN3O
Molecular Weight
328.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14 (2) :413-6.|[2]Li R, et al. Ionizing Radiation Blocks Hair Cell Regeneration in Zebrafish Lateral Line Neuromasts by Preventing Wnt Signaling. Mol Neurobiol. 2018 Feb;55 (2) :1639-1651.|[3]AlMuraikhi N, et al. Inhibition of GSK-3β Enhances Osteoblast Differentiation of Human Mesenchymal Stem Cells through Wnt Signalling Overexpressing Runx2. Int J Mol Sci. 2023 Apr 12;24 (8) :7164. |[4]Chan MH, et al. Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine. Schizophr Res. 2012 Apr;136 (1-3) :96-103.|[5]Shin S, et al. Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1. Oncogene. 2014 Mar 27;33 (13) :1690-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
Available Sizes
Frequently Asked Questions
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