1-Azakenpaullone

1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1].

Product Specifications

CAS Number

[676596-65-9]

Product Name Alternative

1-Akp

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-azakenpaullone.html

Purity

99.61

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CN=C12)CC3=C2NC4=C3C=C(Br)C=C4

Molecular Formula

C15H10BrN3O

Molecular Weight

328.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14 (2) :413-6.|[2]Li R, et al. Ionizing Radiation Blocks Hair Cell Regeneration in Zebrafish Lateral Line Neuromasts by Preventing Wnt Signaling. Mol Neurobiol. 2018 Feb;55 (2) :1639-1651.|[3]AlMuraikhi N, et al. Inhibition of GSK-3β Enhances Osteoblast Differentiation of Human Mesenchymal Stem Cells through Wnt Signalling Overexpressing Runx2. Int J Mol Sci. 2023 Apr 12;24 (8) :7164. |[4]Chan MH, et al. Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine. Schizophr Res. 2012 Apr;136 (1-3) :96-103.|[5]Shin S, et al. Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1. Oncogene. 2014 Mar 27;33 (13) :1690-9.