Glycyl-L-proline

Glycyl-L-proline (H-Gly-Pro-OH) is a dipeptide. Glycyl-L-proline can induce MCF-7 cells apoptosis. Glycyl-L-proline can enhance the inhibitory effect of the PRODH/POX knockout on collagen and DNA biosynthesis. Glycyl-L-proline can inhibit Gly-Sar and L-proline transport. Glycyl-L-proline can be used for the researches of cancer and metabolic disease, such as breast cancer[1][2][3].

Product Specifications

CAS Number

[704-15-4]

Product Name Alternative

H-Gly-Pro-OH; Gly-Pro

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite

Type

Peptides

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/H-Gly-Pro-OH.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 10 mg/mL (ultrasonic)

Smiles

NCC(N1CCC[C@H]1C(O)=O)=O

Molecular Formula

C7H12N2O3

Molecular Weight

172.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Zareba I, et al. Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. Oncotarget. 2018;9 (17) :13748-13757. Published 2018 Feb 9.|[2]von Linde T, et al. Rapid and Sensitive Quantification of Intracellular Glycyl-Sarcosine for Semi-High-Throughput Screening for Inhibitors of PEPT-1. Pharmaceutics. 2021;13 (7) :1019. Published 2021 Jul 3.|[3]Boyd CA, et al. L-proline transport by brush border membrane vesicles prepared from human placenta. J Physiol. 1981;315:9-19.