CK0106023
CK0106023 is a potent and specific allosteric inhibitor of KSP with a Ki value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice[1][2].
Product Specifications
CAS Number
336115-72-1
UNSPSC
12352005
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ck0106023.html
Smiles
O=C1N(CC2=CC=CC=C2)C(C(CC)N(CCCN(C)C)C(C(C=C3)=CC=C3Br)=O)=NC4=C1C=CC(Cl)=C4
Molecular Formula
C30H32BrClN4O2
Molecular Weight
595.96
References & Citations
[1]You-Ling Fan. End-capped polyarylene polyethers, articles made therefrom and process for preparing such polyarylene polyethers. EP0106023B1. 1988 March 30.|[2]Sakowicz R, et al. Antitumor activity of a kinesin inhibitor. Cancer Res. 2004 May 1;64 (9) :3276-80.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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