Human GALP (3-32)

Human GALP (3-32) (Galanin-like peptide (3-32) ) is a potent galanin receptor agonist with high affinity for both GalR1 (IC50=33 nM) and GalR2 (IC50=15 nM) in a competitive binding study. human GALP (3-32) exhibits the high potency in altering the extracellular acidification rate of SH-SY5Y cells transfected with GalR2 (EC50=360 nM) [1].

Product Specifications

Product Name Alternative

Galanin-like peptide (3-32)

UNSPSC

12352209

Target

Neuropeptide Y Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/human-galp-3-32.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(NCC(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N5[C@@H](CCC5)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC(C)C)C(N7[C@@H](CCC7)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Molecular Formula

C137H213N43O38S

Molecular Weight

3102.49

References & Citations

[1]Lang R, et al. Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists. Neuropeptides. 2005 Jun;39 (3) :179-84.