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MAFP

MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.

Product Specifications

Product Name Alternative

Methyl Arachidonyl Fluorophosphonate

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/MAFP.html

Concentration

26.99 mM * 100 μL in Methyl acetate

Purity

98.6

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(OC)(F)=O

Molecular Formula

C21H36FO2P

Molecular Weight

370.48

Precautions

H225, H319, H336

References & Citations

[1]Lio YC, et al. Irreversible inhibition of Ca (2+) -independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta. 1996 Jul 12;1302 (1) :55-60.|[2]Deutsch DG, et al. Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol. 1997 Feb 7;53 (3) :255-60.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, protect from light

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-103334/MAFP-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-103334/MAFP-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[188404-10-6]

Available Sizes

Curated Selection

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