MAFP
MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
Product Specifications
CAS Number
188404-10-6
Product Name Alternative
Methyl Arachidonyl Fluorophosphonate
UNSPSC
12352211
Hazard Statement
H225, H319, H336
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/MAFP.html
Concentration
26.99 mM * 100 μL in Methyl acetate
Purity
98.6
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(OC)(F)=O
Molecular Formula
C21H36FO2P
Molecular Weight
370.48
Precautions
H225, H319, H336
References & Citations
[1]Lio YC, et al. Irreversible inhibition of Ca (2+) -independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta. 1996 Jul 12;1302 (1) :55-60.|[2]Deutsch DG, et al. Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol. 1997 Feb 7;53 (3) :255-60.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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