Eclitasertib
Eclitasertib (DNL-758) is a potent receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 of 0.0375 µΜ[1].
Product Specifications
CAS Number
[2125450-76-0]
Product Name Alternative
DNL-758; SAR-443122
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/eclitasertib.html
Purity
99.77
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=NC=CC=C4OC3)=O
Molecular Formula
C19H18N6O3
Molecular Weight
378.38
References & Citations
[1]Anthony A. ESTRADA, et al. Compounds, compositions and methods. WO2017136727A2.|[2]Darwish I, et al., Rip1k inhibitors. WO2021203011
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
Available Sizes
Curated Selection
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