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Diaveridine

Diaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent.

Product Specifications

CAS Number

5355-16-8

Product Name Alternative

EGIS-5645

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antifolate; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Diaveridine.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

NC1=NC=C(CC2=CC=C(OC)C(OC)=C2)C(N)=N1

Molecular Formula

C13H16N4O2

Molecular Weight

260.29

Precautions

H315, H319, H335

References & Citations

[1]Sirichaiwat C et al. Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. J Med Chem 47:345-54 (2004) .|[2]Ono T, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3 (4) :297-306.|[3]Wang J, et al. Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodents. Environ Toxicol Pharmacol. 2015 Sep;40 (2) :660-70.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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