Diaveridine
Product Specifications
UNSPSC Description
Diaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent.
Target Antigen
Antifolate; Bacterial
Type
Reference compound
Related Pathways
Anti-infection;Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Diaveridine.html
Purity
99.79
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
NC1=NC=C(CC2=CC=C(OC)C(OC)=C2)C(N)=N1
Molecular Weight
260.29
References & Citations
[1]Sirichaiwat C et al. Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. J Med Chem 47:345-54 (2004).|[2]Ono T, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306.|[3]Wang J, et al. Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodents. Environ Toxicol Pharmacol. 2015 Sep;40(2):660-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1902/Diaveridine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1902/Diaveridine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
5355-16-8
Available Sizes
Curated Selection
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