Chaparrinone

Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC50: 0.037 and 0.34 μg/mL respectively) [1][2].

Product Specifications

CAS Number

[22611-34-3]

UNSPSC

12352005

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/chaparrinone.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]3([H])[C@@]45[C@@](OC(C[C@@]4([H])[C@H]([C@H]([C@@]3(OC5)O)O)C)=O)([H])C[C@@]1([H])C(C)=CC([C@H]2O)=O

Molecular Formula

C20H26O7

Molecular Weight

378.42

References & Citations

[1]Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57 (8) :1205-8.|[2]François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28 (4) :635-40.