Anpirtoline
Anpirtoline (D-16949) is a centrally acting 5-HT1B receptor agonist, with Kis of 28 nM (5-HT1B), 150 nM (5-HT1A) and 1.49 μM (5-HT2) . Anpirtoline has serotonergic, antinociceptive, antidepressant-like effects[1][2][3].
Product Specifications
CAS Number
98330-05-3
Product Name Alternative
D-16949
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anpirtoline.html
Smiles
ClC1=NC(SC2CCNCC2)=CC=C1
Molecular Formula
C10H13ClN2S
Molecular Weight
228.74
References & Citations
[1]Swedberg MD, et al. D-16949 (anpirtoline) : a novel serotonergic (5-HT1B) psychotherapeutic agent assessed by its discriminative effects in the rat. J Pharmacol Exp Ther. 1992 Dec;263 (3) :1015-22.|[2]Chien PY, et al. The dorsal raphe-to-ventral hippocampal projection modulates reactive aggression through 5-HT1B receptors. Eur J Pharmacol. 2024 Oct 15;981:176918.|[3]Schlicker E, et al. Anpirtoline, a novel, highly potent 5-HT1B receptor agonist with antinociceptive/antidepressant-like actions in rodents. Br J Pharmacol. 1992 Mar;105 (3) :732-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
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