DTX-P7
Product Specifications
UNSPSC Description
DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90[1].
Target Antigen
Apoptosis; Eukaryotic Initiation Factor (eIF); HSP; Peptide-Drug Conjugate (PDC); PERK
Type
Peptides
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dtx-p7.html
Smiles
O=C(OC(C)(C)C)N[C@H]([C@@H](OC(CCC(N[C@@H](CC(C)C)C(N1[C@H](C(N[C@H](C(N[C@@H]([C@H](O)C)C(N2CCC[C@H]2C(N[C@@H](CC(C)C)C(N3CCC[C@H]3C(O)=O)=O)=O)=O)=O)CC(C)C)=O)CCC1)=O)=O)=O)C(O[C@@H]4C(C)=C([C@@H](O)C([C@@]5(C)[C@]([C@@](CO6)(OC(C)=O)[C@@]6([H])C[C@@H]5O)([H])[C@@H]7OC(C8=CC=CC=C8)=O)=O)C(C)(C)[C@@]7(O)C4)=O)C9=CC=CC=C9
Molecular Weight
1639.87
References & Citations
[1]Yao Jiang, et al. DTX-P7, a peptide-drug conjugate, is highly effective for non-small cell lung cancer. J Hematol Oncol. 2022 Jun 3;15(1):73.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10757/DTX-P7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10757/
Clinical Information
No Development Reported
Curated Selection
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