(E) -8- (3-Chlorostyryl) caffeine

(E) -8- (3-Chlorostyryl) caffeine is a selective adenosine A2A receptor antagonist. (E) -8- (3-Chlorostyryl) caffeine inhibits monoamine oxidase B (MAO-B) with a Ki value of 70 nM by a pathway that is independent of its actions on the A2A receptor. (E) -8- (3-Chlorostyryl) caffeine has the potential for Parkinson's disease research[1].

Product Specifications

CAS Number

[147700-11-6]

UNSPSC

12352005

Target

Adenosine Receptor; Monoamine Oxidase

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-8-3-chlorostyryl-caffeine.html

Purity

99.4

Solubility

DMSO : 8.27 mg/mL (ultrasonic; warming)

Smiles

CN1C2=C(N(C(N(C2=O)C)=O)C)N=C1/C=C/C3=CC(Cl)=CC=C3

Molecular Formula

C16H15ClN4O2

Molecular Weight

330.77

References & Citations

[1]Nevil Vlok, et al. Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E) -8- (3-chlorostyryl) caffeine (CSC) . Bioorg Med Chem. 2006 May 15;14 (10) :3512-21.