(E)-8-(3-Chlorostyryl)caffeine
Product Specifications
UNSPSC Description
(E)-8-(3-Chlorostyryl)caffeine is a selective adenosine A2A receptor antagonist. (E)-8-(3-Chlorostyryl)caffeine inhibits monoamine oxidase B (MAO-B) with a Ki value of 70 nM by a pathway that is independent of its actions on the A2A receptor. (E)-8-(3-Chlorostyryl)caffeine has the potential for Parkinson's disease research[1].
Target Antigen
Adenosine Receptor; Monoamine Oxidase
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-8-3-chlorostyryl-caffeine.html
Purity
99.00
Solubility
DMSO : 8.27 mg/mL (ultrasonic;warming)
Smiles
CN1C2=C(N(C(N(C2=O)C)=O)C)N=C1/C=C/C3=CC(Cl)=CC=C3
Molecular Weight
330.77
References & Citations
[1]Nevil Vlok, et al. Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorg Med Chem. 2006 May 15;14(10):3512-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103164/E-8-3-Chlorostyryl-caffeine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103164/E-8-3-Chlorostyryl-caffeine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
147700-11-6
Available Sizes
Curated Selection
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