L-Citronellol

L-Citronellol ((S) -3,7-Dimethyloct-6-en-1-ol) is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces TNF-α expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD) [1][2].

Product Specifications

CAS Number

[7540-51-4]

Product Name Alternative

(S) -3,7-Dimethyloct-6-en-1-ol

UNSPSC

12352211

Hazard Statement

H315, H317, H319, H402

Target

Beta-secretase; Cholinesterase (ChE) ; ERK; TNF Receptor; γ-secretase

Type

Natural Products

Related Pathways

Apoptosis; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-citronellol.html

Purity

99.97

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

C/C(C)=C\CC[C@H](C)CCO

Molecular Formula

C10H20O

Molecular Weight

156.27

Precautions

H315, H317, H319, H402

References & Citations

[1]Zhou J, et al. Natural compounds for Alzheimer's prevention and treatment: Integrating SELFormer-based computational screening with experimental validation. Comput Biol Med. 2025 Feb;185:109523.|[2]Kobayashi Y, et al. Inhibitory effects of geranium essential oil and its major component, citronellol, on degranulation and cytokine production by mast cells. Biosci Biotechnol Biochem. 2016 Jun;80 (6) :1172-8.