WD6305 (TFA)
WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 TFA has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 TFA inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 TFA has antitumor activity[1]. (Pink: UZH2 ; Black: Linker; Blue: VHL ligand (HY-150803) )
Product Specifications
UNSPSC
12352005
Target
Apoptosis; METTL3; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wd6305-tfa.html
Purity
99.81
Solubility
DMSO : 95 mg/mL (ultrasonic)
Smiles
Molecular Formula
C63H76F5N11O7S
Molecular Weight
1226.40
References & Citations
[1]Du W, et al. Discovery of a PROTAC degrader for METTL3-METTL14 complex. Cell Chem Biol. 2024 Jan 2:S2451-9456 (23) 00439-7
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cancer Res. 2025 Aug 27.|RSC Med Chem. 2025 Jun 19.
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