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WD6305 (TFA)

WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 TFA has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 TFA inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 TFA has antitumor activity[1]. (Pink: UZH2 (HY-115717) ; Black: Linker; Blue: VHL ligand (HY-150803) )

Product Specifications

UNSPSC

12352005

Target

Apoptosis; METTL3; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/wd6305-tfa.html

Purity

99.81

Solubility

DMSO : 95 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCC#CC(C=C4)=CC=C4CNC5=CC(N(CC6)CCC76NC(CN(C8=CC(F)=C(CN9CCC(C)(C)CC9)C=C8F)C7)=O)=NC=N5.O=C(O)C(F)(F)F

Molecular Formula

C63H76F5N11O7S

Molecular Weight

1226.40

References & Citations

[1]Du W, et al. Discovery of a PROTAC degrader for METTL3-METTL14 complex. Cell Chem Biol. 2024 Jan 2:S2451-9456 (23) 00439-7

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Cancer Res. 2025 Aug 27.|RSC Med Chem. 2025 Jun 19.

Available Sizes

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