IQGAP1 Recombinant Rabbit Monoclonal Antibody [JE50-66]
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton such as the formin Dia1 (mDia1), with cell adhesion molecules (CAMs), and with several signaling molecules to regulate cell morphology and motility. For example, IQGAP1 expression is necessary for neuronal process outgrowth on the cell adhesion molecule PTPmu (PTPRM). Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines and its over-expression and distinct membrane localisation is also observed in a range of tumours.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
IQGAP1, KIAA0051
Swiss Prot
P46940 Human, Q9JKF1 Mouse, B5DFH1 Rat
Cellular Locus
Cell membrane, Nucleus, Cytoplasm, Apical cell membrane, Basolateral cell membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human IQGAP1 aa 1-50 / 1,657.
Isotype
IgG
Clone
JE50-66
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
HeLa cell lysate, 293T cell lysate, MDA-MB-231 cell lysate, RAW264.7 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, HeLa, human liver tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:4,000 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size:
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Mucin 5AC (MUC5AC) (45M1), CF740 conjugate, 0.1mg/mL
CD81 / TAPA-1 (1.3.3.22), CF740 conjugate, 0.1mg/mL
GFAP (Astrocyte & Neural Stem Cell Marker) (GFAP/2076), CF594 conjugate, 0.1mg/mL
