SAMβA (TFA)
SAMβA TFA is conjugated to the cell permeable peptide TAT47-57. SAMβA TFA, a rationally designed selective antagonist of Mfn1-βIIPKC association. SAMβA TFA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats[1].
Product Specifications
UNSPSC
12352209
Target
PKC
Type
Peptides
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/samβa-tfa.html
Purity
99.13
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.OC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CC(N)=O)=O)C)=O)CCC(O)=O)=O)CC(N)=O)=O)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CC2=CC=CC=C2)=O.[x]
Molecular Formula
C50H73N17O16.xC2HF3O2
Molecular Weight
1168.22 (free acid)
References & Citations
[1]Julio C B Ferreira A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun. 2019 Jan 18;10 (1) :329.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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