Cyclo (L-Pro-L-Val)

Cyclo (L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo (L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239) . Cyclo (L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo (L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases[1][2].

Product Specifications

CAS Number

[2854-40-2]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cyclo-l-pro-l-val.html

Purity

98.14

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H]1C(C)C)[C@@](CCC2)([H])N2C1=O

Molecular Formula

C10H16N2O2

Molecular Weight

196.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Cimmino A, et al. Isolation of 2,5-diketopiperazines from Lysobacter capsici AZ78 with activity against Rhodococcus fascians. Nat Prod Res. 2021 Dec;35 (23) :4969-4977.|[2]Lee D, et al. Bioactive Phytochemicals from Mulberry: Potential Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. Int J Mol Sci. 2021 Jul 29;22 (15) :8120.