Chimaphilin

Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM) . Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2].

Product Specifications

CAS Number

[482-70-2]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

IGF-1R

Type

Natural Products

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/chimaphilin.html

Solubility

10 mM in DMSO

Smiles

O=C1C(C)=CC(C2=C1C=C(C)C=C2)=O

Molecular Formula

C12H10O2

Molecular Weight

186.21

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Daqian W, et al. Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling. Chem Biol Interact. 2015 Jul 25;237:25-30.|[2]Ma WD, et al. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014 Aug;70:1-8.