2'-F-Bz-dC Phosphoramidite

2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA) . 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells[1][2][3].

Product Specifications

CAS Number

[161442-19-9]

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335, H360

Target

DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-f-bz-dc-phosphoramidite.html

Purity

99.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N4C=CC(NC(C5=CC=CC=C5)=O)=NC4=O)O3)C6=CC=CC=C6)C=C1

Molecular Formula

C46H51FN5O8P

Molecular Weight

851.90

Precautions

H315, H317, H319, H335, H360

References & Citations

[1]Reif B, et, al. Structural Comparison of Oligoribonucleotides and Their 2′-Deoxy-2′-fluoro Analogs by heteronuclear NMR spectroscopy. Helvetica Chimica Acta. 1997 Jou; 80 (6) : 1952-1971.|[2]Zhang Hongyan, et al. Combined drug for treating hepatitis B and its application in preparing drugs for preventing and/or treating HBV (hepatitis B virus) -induced symptom or diseases. China, CN112007040 A. 2020-12-01. |[3]Monia Brett P, et al. Antisense oligonucleotides for modulation of telomerase catalytic subunit gene expression and treatment of cancer. World Intellectual Property Organization, WO2001088198 A1. 2001-11-22.