KS124

KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production[1].

Product Specifications

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH) ; Apoptosis; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ks124.html

Smiles

O=C(C1=CC=C([N+]([O-])=O)O1)OCC2=CC=C(CN3C(C(C4=C3C(Br)=CC(Br)=C4)=O)=O)C=C2

Molecular Formula

C21H12Br2N2O7

Molecular Weight

564.14

References & Citations

[1]Gowda K, et al. Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor. Molecules. 2024 Jun 29;29 (13) :3114.