DBCO-NHCO-PEG6-Biotin

DBCO-NHCO-PEG6-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NHCO-PEG6-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[3081794-36-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-nhco-peg6-biotin.html

Purity

96.65

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1)N[C@](CS2)([H])[C@@]1([H])[C@@H]2CCCCC(NCCOCCOCCOCCOCCOCCOCCC(NCCC(N3C4=CC=CC=C4C#CC5=CC=CC=C5C3)=O)=O)=O

Molecular Formula

C43H59N5O10S

Molecular Weight

838.02

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562