FC131

FC131 is a potent CXCR4 antagonist. FC131 inhibits [125I]-SDF-1 binding to CXCR4 with an IC50 of 4.5 nM. FC131 has anti-HIV activity[1].

Product Specifications

CAS Number

[606968-52-9]

UNSPSC

12352209

Target

CXCR; HIV

Type

Peptides

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fc131.html

Solubility

H2O

Smiles

O=C([C@@H](NC([C@@H](NC([C@@H](CC1=CC=C(O)C=C1)NC(CNC2=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)N[C@H]2CC3=CC4=C(C=CC=C4)C=C3

Molecular Formula

C36H47N11O6

Molecular Weight

729.83

References & Citations

[1]Tamamura H, et al. Stereoselective synthesis of [L-Arg-L/D-3- (2-naphthyl) alanine]-type (E) -alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 Jan 27;48 (2) :380-91.