SHR1653
SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC50 of 15 nM for hOTR[1].
Product Specifications
CAS Number
[2231770-73-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Oxytocin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/shr1653.html
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(N2C(N3C[C@@]4(C5=CC=C(F)C=C5Cl)C[C@@]4([H])C3)=NN=C2COC)C=N1
Molecular Formula
C21H21ClFN5O2
Molecular Weight
429.88
Precautions
H302, H315, H319, H335
References & Citations
[1]Li X, et al. Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration. ACS Med Chem Lett. 2019 May 29;10 (6) :996-1001.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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