SHR1653

SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC50 of 15 nM for hOTR[1].

Product Specifications

CAS Number

[2231770-73-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Oxytocin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/shr1653.html

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C(N2C(N3C[C@@]4(C5=CC=C(F)C=C5Cl)C[C@@]4([H])C3)=NN=C2COC)C=N1

Molecular Formula

C21H21ClFN5O2

Molecular Weight

429.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Li X, et al. Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration. ACS Med Chem Lett. 2019 May 29;10 (6) :996-1001.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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