BVDU 5′-Triphosphate (ammonium)

BVDU 5′-Triphosphate ammonium is an antivirus agent with 5′-Triphosphate label, targeting viral DNA polymerase. BVDU 5′-Triphosphate ammonium shows excellent selectivity against varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1), due to a specific phosphorylation by the virus-encoded thymidine kinase.

Product Specifications

Product Name Alternative

(E) -5- (2-Bromovinyl) -dUTP (ammonium) ; BVdUTP (ammonium)

UNSPSC

12352005

Target

HSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bvdu-5-triphosphate-ammonium.html

Purity

98.0

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

OP(OP(OP(O)(OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(/C=C/Br)=C2)=O)=O)O1)=O)(O)=O)(O)=O.N

Molecular Formula

C11H19BrN3O14P3

Molecular Weight

590.11

References & Citations

[1]De Clercq E. Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster. Biochem Pharmacol. 2004 Dec 15;68 (12) :2301-15.