Apixaban-13C, d3

Apixaban-13C, d3 (BMS-562247-01-13C, d3) is a deuterium and 13C labeled Apixaban (HY-50667) . Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1].

Product Specifications

CAS Number

[1261393-15-0]

Product Name Alternative

BMS-562247-01-13C, d3

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

Factor Xa

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

99.53

Solubility

DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC(C1=NN(C2=C1CCN(C2=O)C3=CC=C(C=C3)N4CCCCC4=O)C5=CC=C(C=C5)O[13C]([2H])([2H])[2H])=O

Molecular Formula

C24 13CH22D3N5O4

Molecular Weight

463.51

Precautions

H302, H315, H320, H335

References & Citations

[1]Pinto DJ, et al. Discovery of 1- (4-methoxyphenyl) -7-oxo-6- (4- (2-oxopiperidin-1-yl) phenyl) -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem. 2007 Nov 1;50 (22) :5339-56.