Validamine
Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC50 value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme[1].
Product Specifications
CAS Number
[32780-32-8]
Product Name Alternative
(1R,2S,3S,4S,6R) -4-Amino-6- (hydroxymethyl) cyclohexane-1,2,3-triol
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Glycosidase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/validamine.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@H]([C@@H]([C@@H](O)[C@@H](N)C1)O)O
Molecular Formula
C7H15NO4
Molecular Weight
177.20
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Takeuchi M, et al. Inhibitory effect of validamine, valienamine and valiolamine on activities of carbohydrases in rat small intestinal brush border membranes. Chem Pharm Bull (Tokyo) . 1990 Jul;38 (7) :1970-2.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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