Auramine O

Auramine O is a yellow fluorescent dye. Auramine O is used to detect amyloid fibrils. Auramine O promotes lung malignancy. Auramine O is also used to determine algal cell viability and stain acid-fast bacteria[1][2][3][4][5][6].

Product Specifications

CAS Number

[2465-27-2]

UNSPSC

12171500

Hazard Statement

H302, H319, H351, H411

Target

Amyloid-β; Fluorescent Dye

Type

Dye Reagents

Related Pathways

Neuronal Signaling; Others

Field of Research

Neurological Disease; Others

Assay Protocol

https://www.medchemexpress.com/auramine-o.html

Purity

95.0

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N=C(C1=CC=C(N(C)C)C=C1)C2=CC=C(N(C)C)C=C2.[H]Cl

Molecular Formula

C17H22ClN3

Molecular Weight

303.84

Precautions

H302, H319, H351, H411

References & Citations

[1]Kommareddi S, et al. Nontuberculous mycobacterial infections: comparison of the fluorescent auramine-O and Ziehl-Neelsen techniques in tissue diagnosis. Hum Pathol. 1984 Nov;15 (11) :1085-9. |[2]Hosseinpour S A, et al. Use of metal composite MOF‐5‐Ag2O‐NPs as an adsorbent for the removal of Auramine O dye under ultrasound energy conditions. Applied Organometallic Chemistry, 2018, 32 (2) : e4007.|[3]Gizaw N, et al. The yield of Auramine O staining using led microscopy with bleach treated sputum samples for detection of pulmonary tuberculosis at St. Peter tuberculosis specialized hospital, Addis Ababa, Ethiopia. J Clin Tuberc Other Mycobact Dis. 2019 Dec 12;18:100140.|[4]Amdursky N, et al. Auramine-O as a fluorescence marker for the detection of amyloid fibrils. J Phys Chem B. 2012 Nov 15;116 (45) :13389-95.|[5]Tung JC, et al. Auramine O, an incense smoke ingredient, promotes lung cancer malignancy. Environ Toxicol. 2017 Nov;32 (11) :2379-2391.|[6]Hawes I, et al. Use of the fluorochrome Auramine O for determination of cell viability in filamentous and thalloid algae. Phycologia, 1989, 28 (4) : 518-520.