TM5275 (sodium)

TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 μM.

Product Specifications

CAS Number

[1103926-82-4]

UNSPSC

12352005

Hazard Statement

H302, H400

Target

PAI-1

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/TM5275_sodium.html

Purity

98.97

Solubility

DMSO : 58.33 mg/mL (ultrasonic)

Smiles

O=C(O[Na])C1=CC(Cl)=CC=C1NC(COCC(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)=O

Molecular Formula

C28H27ClN3NaO5

Molecular Weight

543.97

Precautions

H302, H400

References & Citations

[1]Izuhara Y, et al. A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates. J Cereb Blood Flow Metab. 2010 May;30 (5) :904-12.|[2]Yasui H, et al. TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells. Thromb Res. 2013 Jul;132 (1) :100-5.|[3]Mashiko S, et al. Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer. Cancer Biol Ther. 2015;16 (2) :253-60.