PROTAC Vif degrader-1
PROTAC Vif degrader-1 (Compound L15) is a Vif PROTAC degrader. PROTAC Vif degrader-1 has antiviral activity against HIV-1 (EC50: 33.35 μM against HIV-1IIIB). Blue: CRBN ligand ; Black: linker; Pink: HIV-1 inhibitor (HY-163852).
Product Specifications
UNSPSC
12352005
Target
HIV; PROTACs
Type
Reference compound
Related Pathways
Anti-infection; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/protac-vif-degrader-1.html
Smiles
COC1=CC=C(C=C1NC(C2=C(C=CC=C2SC3=CC=C(C=C3)[N+]([O-])=O)N)=O)OCC(NCCOCCOCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O
Molecular Formula
C41H41N7O12S
Molecular Weight
855.87
References & Citations
[1]Luo D, et al. Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1. Bioorg Med Chem Lett. 2024 Jul 10;111:129880.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Frequently Asked Questions
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