Cot inhibitor-1

Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM[1].

Product Specifications

CAS Number

[915365-57-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAP3K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cot-inhibitor-1.html

Purity

98.45

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

N#CC1=C(C2=CC(NCC3=CN(CCN4CCCCCC4)N=N3)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5

Molecular Formula

C27H27Cl2FN8

Molecular Weight

553.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19 (13) :3485-8.