Recombinant Human CCL27

Recombinant human CCL27

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

rHuCCL27, CTACK

Gene Name

CCL27

UniProt

Q9Y4X3

Cellular Locus

Secreted

Reactivity

Human

Target Antigen

C-C motif chemokine 27

Target

CCL27

Type

Protein

Applications

Migration assay

Dilution

Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.

Form

Lyophilized

Function

Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Additionnal Information

Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay in L1.2 cells expressing CCR10.

Storage Conditions

12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution.

Specificity

CCL27

Target Background

CCL27, also known as Cutaneous T-cell-attracting Chemokine (CTACK) is a ligand for cell surface receptor CCR10. It is responsible for chemotaxis of skin-homing memory T-cells during cutaneous inflammation. Interestingly, after CCR10-mediated internalization, CCL27, as well as a non-secreted splice variant of the same gene, can reach the nucleus and modulate transcription and cell behavior.